Ishq Katileyana is a romantic thriller that revolves around the life of a young woman named Aaradhya, played by actress Aisha Kaduskar. Aaradhya is a successful businesswoman who has it all – a thriving career, a loving family, and a supportive network of friends. However, her life takes a dramatic turn when she meets her new neighbor, the charming and enigmatic, Karan.