Corrupted game files can cause crashes. Verify the integrity of your game files:
By following the steps outlined in this guide—starting with the 4GB patch and moving through compatibility settings, file verification, and ensuring PhysX is properly installed—you can resolve the vast majority of crashes. the testament of sherlock holmes crash fix
Ensure you have both the versions of the Microsoft Visual C++ 2010 Redistributable installed. Many users find that reinstalling these specifically fixes "Startup Crashes." 6. Adjusting the Setup.ini (Advanced) Corrupted game files can cause crashes