The movie begins with Rizwan Khan, a shy and introverted man with Asperger's syndrome, who lives in the United States with his sister. He meets Ishita, a beautiful and kind-hearted woman, and falls deeply in love with her. The two get married, and Rizwan moves to India with Ishita. However, their happiness is short-lived, as Rizwan faces numerous challenges due to his Muslim identity in a predominantly Hindu country.